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Crystal structure analysis of the C domain of synapsin II from rat brain

Analyse Crystal structure analysis of the C domain of synapsin II from rat brain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1I7N
Type: protein
Length: 616 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Synapsin II
UniProt: Q63537
Pockets: 8 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Synapsin II	protein	308	29% helix, 31% strand	Q63537

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	320	0.75	0.87	55	empty
2	477	0.74	0.83	65	empty
3	97	0.67	0.91	21	empty
4	449	0.62	0.77	56	empty
5	131	0.38	0.73	29	empty

Interfaces

1 interface between chains.

A–B · 1950 Å² buried · 30 hydrogen bonds · protein-protein

Compared structures

1I7N · Crystal structure analysis of the C domain of synapsin II from rat brain · the same entry in another collection · chain A against A, TM-score 1.00
Q63537 · AlphaFold monomer V2.0 prediction for synapsin-2 (Q63537) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q63537
Elsewhere: RCSB PDB 1I7N · PDBe 1I7N · UniProt Q63537

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