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Crystal structure of the otu domain of GUMBY/FAM105B at 1.6 ångström

Analyse Crystal structure of the otu domain of GUMBY/FAM105B at 1.6 ångström in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4KSJ
Type: protein
Length: 259 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein FAM105B
UniProt: Q96BN8
Pockets: 2 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 57% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein FAM105B	protein	259	57% helix, 12% strand	Q96BN8

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains A
BME · Beta-mercaptoethanol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	68	0.40	0.79	12	empty
2	80	0.33	0.75	21	empty

Modifications

Observed in the structure: 9 modified, 1 covalent (engineered, additive adduct).

Compared structures

4KSJ · Crystal structure of the OTU domain of Gumby/Fam105B at 1.6 angstrom · the same entry in another collection · chain A against A, TM-score 1.00
Q96BN8 · AlphaFold monomer V2.0 prediction for ubiquitin thioesterase otulin (Q96BN8) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96BN8
Elsewhere: RCSB PDB 4KSJ · PDBe 4KSJ · UniProt Q96BN8

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