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Crystal structure of anti-il-17A antibody CNTO3186

Analyse Crystal structure of anti-il-17A antibody CNTO3186 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4KQ3
Type: protein
Length: 428 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CNTO3186 light chain; CNTO3186 heavy chain
Pockets: 3 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	CNTO3186 light chain	protein	211	6% helix, 53% strand	—
H	CNTO3186 heavy chain	protein	217	7% helix, 52% strand	—

Ligands and binding sites

GOL · Glycerol · additive · 3 copies · chains L, H
MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains H
EDO · 1,2-ethanediol · additive · chains H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	718	0.66	0.75	62	GOL, MES
2	86	0.35	0.75	20	empty
3	62	0.27	0.72	18	empty

Interfaces

1 interface between chains.

L–H · 1843 Å² buried · 22 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide, 1 modified (disulfide, cyclization).

Compared structures

4KQ3 · Crystal structure of Anti-IL-17A antibody CNTO3186 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4KQ3 · PDBe 4KQ3

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