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Crystal structure of MYCP1 from the esx-1 type VII secretion system

Analyse Crystal structure of MYCP1 from the esx-1 type VII secretion system in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4KPG
Type: protein
Length: 383 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Membrane-anchored mycosin MYCP1
EC: 3.4.21.62
UniProt: A0QNL1
Pockets: 3 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 25% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Membrane-anchored mycosin MYCP1 (EC 3.4.21.62)	protein	383	25% helix, 20% strand	A0QNL1

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	540	0.68	0.78	53	empty
2	94	0.38	0.76	20	empty
3	70	0.31	0.74	19	empty

Modifications

Observed in the structure: 5 modified, 2 disulfide (engineered, disulfide).

Compared structures

4KPG · Crystal structure of MycP1 from the ESX-1 type VII secretion system · the same entry in another collection · chain A against A, TM-score 1.00
A0QNL1 · AlphaFold monomer V2.0 prediction for mycosin-1 (A0QNL1) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0QNL1
Elsewhere: RCSB PDB 4KPG · PDBe 4KPG · UniProt A0QNL1

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