Research workbench
Structure of a putative transcriptional regulator of laci family from sanguibacter keddieii dsm 10542.
Analyse Structure of a putative transcriptional regulator of laci family from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4KMR
- Type
- protein
- Length
- 539 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator, laci family
- UniProt
- D1BJM2
- Ligands
- MG, NA
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional regulator, laci family | protein | 272 | 40% helix, 16% strand | D1BJM2 |
| B | Transcriptional regulator, laci family | protein | 267 | 41% helix, 18% strand | D1BJM2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1118 | 0.78 | 0.80 | 118 | empty |
| 2 | 71 | 0.72 | 0.96 | 20 | empty |
| 3 | 161 | 0.45 | 0.76 | 21 | empty |
| 4 | 77 | 0.39 | 0.78 | 19 | empty |
| 5 | 76 | 0.37 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1495 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 modified (engineered).
Compared structures
- 4KMR · Structure of a putative transcriptional regulator of LacI family from Sanguibacter… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D1BJM2
- Elsewhere: RCSB PDB 4KMR · PDBe 4KMR · UniProt D1BJM2
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