Research workbench

Formation of a protein intermediate and its trapping by the simultaneous crystallization process: crystal structure of an iron-saturated intermediate in the FE3+ binding pathway of camel lactoferrin at 2.7 resolution

Analyse Formation of a protein intermediate and its trapping by the simultaneous… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1I6Q
Type: protein
Length: 689 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lactoferrin
UniProt: Q9TUM0
Ligands: FE, CO3
Pockets: 8 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lactoferrin	protein	689	29% helix, 19% strand	Q9TUM0

Ligands and binding sites

FE · Fe (III) ion · metal · 2 copies · chains A
CO3 · Carbonate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	350	0.72	0.84	38	empty
2	215	0.57	0.80	24	empty
3	329	0.55	0.75	44	FE, CO3
4	192	0.46	0.74	37	empty
5	91	0.38	0.76	16	empty

Modifications

Observed in the structure: 15 disulfide (disulfide).

Compared structures

1I6Q · Formation of a protein intermediate and its trapping by the simultaneous crystallization… · the same entry in another collection · chain A against A, TM-score 1.00
Q9TUM0 · AlphaFold monomer V2.0 prediction for lactotransferrin (Q9TUM0) · a predicted model of the same protein · chain A against A, TM-score 0.68

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9TUM0
Elsewhere: RCSB PDB 1I6Q · PDBe 1I6Q · UniProt Q9TUM0

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.