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Crystal structure of a chimeric FPP/GFPP synthase (target efi-502313C) from artemisia spiciformis (1-72:GI751454468,73-346:GI75233326), apo structure
Analyse Crystal structure of a chimeric FPP/GFPP synthase (target efi-502313C) from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4KK2
- Type
- protein
- Length
- 674 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monoterpene synthase fds-5, chloroplastic - farnesyl diphosphate synthase 1 chimera
- EC
- 2.5.1.67, 2.5.1.1, 2.5.1.69, 2.5.1.10
- UniProt
- Q7XYS8, Q7XYS9
- Pockets
- 9 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Monoterpene synthase fds-5, chloroplastic - farnesyl diphosphate synthase 1 chimera (EC 2.5.1.67, 2.5.1.1, 2.5.1.69, 2.5.1.10) | protein | 338 | 74% helix, 1% strand | Q7XYS8, Q7XYS9 |
| B | Monoterpene synthase fds-5, chloroplastic - farnesyl diphosphate synthase 1 chimera (EC 2.5.1.67, 2.5.1.1, 2.5.1.69, 2.5.1.10) | protein | 336 | 75% helix, 1% strand | Q7XYS8, Q7XYS9 |
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 830 | 0.74 | 0.78 | 58 | empty |
| 2 | 838 | 0.72 | 0.77 | 57 | empty |
| 3 | 144 | 0.45 | 0.76 | 22 | empty |
| 4 | 108 | 0.45 | 0.78 | 20 | empty |
| 5 | 110 | 0.41 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 2412 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 4KK2 · Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia… · the same entry in another collection · chain A against A, TM-score 1.00
- Q7XYS9 · AlphaFold monomer V2.0 prediction for farnesyl diphosphate synthase 1 (Q7XYS9) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q7XYS8 · AlphaFold monomer V2.0 prediction for monoterpene synthase fds-5, chloroplastic (Q7XYS8) · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7XYS8
- Every structure of UniProt Q7XYS9
- Elsewhere: RCSB PDB 4KK2 · PDBe 4KK2 · UniProt Q7XYS8 · UniProt Q7XYS9
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