Research workbench
Crystal structure of selenium substituted CA2+/H+ antiporter proteinyfke
Analyse Crystal structure of selenium substituted CA2+/H+ antiporter proteinyfke in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4KJR
- Type
- protein
- Length
- 636 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cation exchanger yfke
- UniProt
- O34840
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cation exchanger yfke | protein | 325 | 81% helix, 0% strand | O34840 |
| B | Cation exchanger yfke | protein | 311 | 81% helix, 0% strand | O34840 |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1102 | 0.77 | 0.79 | 94 | empty |
| 2 | 399 | 0.68 | 0.80 | 49 | empty |
| 3 | 340 | 0.61 | 0.78 | 39 | empty |
| 4 | 257 | 0.53 | 0.75 | 37 | empty |
| 5 | 78 | 0.45 | 0.81 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 575 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 modified (engineered).
Compared structures
- 4KJR · Crystal structure of selenium substituted Ca2+/H+ antiporter proteinYfkE · the same entry in another collection · chain A against A, TM-score 1.00
- O34840 · AlphaFold monomer V2.0 prediction for CA(2+)/H(+) antiporter chaa (O34840) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O34840
- Elsewhere: RCSB PDB 4KJR · PDBe 4KJR · UniProt O34840
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