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Crystal structure of a pseudo-16-mer DNA with stacked guanines and two G-a mispairs complexed with the N- terminal fragment of moloney murine leukemia virus reverse transcriptase
Analyse Crystal structure of a pseudo-16-mer DNA with stacked guanines and two G-a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1I6J
- Type
- protein + DNA
- Length
- 272 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-D(*GP*TP*CP*GP*TP*C)-3'; 5'-D(*AP*CP*GP*GP*GP*AP*CP*GP*AP*C)-3'; Reverse transcriptase
- EC
- 2.7.7.49
- UniProt
- P03355
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 3 distinct chains · 31% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | 5'-D(*GP*TP*CP*GP*TP*C)-3' | dna | 6 | — | — |
| C | 5'-D(*AP*CP*GP*GP*GP*AP*CP*GP*AP*C)-3' | dna | 10 | — | — |
| A | Reverse transcriptase (EC 2.7.7.49) | protein | 256 | 31% helix, 24% strand | P03355 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 256 | 0.52 | 0.75 | 27 | empty |
| 2 | 176 | 0.48 | 0.77 | 27 | empty |
Interfaces
3 interfaces between chains.
- B–C · 259 Ų buried · 23 hydrogen bonds · nucleic-nucleic
- B–A · 235 Ų buried · 6 hydrogen bonds · protein-nucleic
- C–A · 190 Ų buried · 3 hydrogen bonds · protein-nucleic
Compared structures
- 1I6J · Crystal structure of a pseudo-16-mer DNA with stacked guanines and two G-a mispairs… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03355
- Elsewhere: RCSB PDB 1I6J · PDBe 1I6J · UniProt P03355
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