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Crystal structure of double leucine to methionine mutant human SPLUNC1 lacking the secretion signal sequence

Analyse Crystal structure of double leucine to methionine mutant human SPLUNC1 lacking… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4KGO
Type: protein
Length: 386 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bpi fold-containing family a member 1
UniProt: Q9NP55
Pockets: 1 · best druggability 0.36

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Bpi fold-containing family a member 1	protein	203	37% helix, 29% strand	Q9NP55
A	Bpi fold-containing family a member 1	protein	183	34% helix, 28% strand	Q9NP55

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	104	0.36	0.74	19	empty

Interfaces

1 interface between chains.

B–A · 760 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified, 2 disulfide (engineered, disulfide).

Compared structures

4KGO · Crystal Structure of double Leucine to Methionine mutant human splunc1 lacking the… · the same entry in another collection · chain B against B, TM-score 1.00
Q9NP55 · AlphaFold monomer V2.0 prediction for bpi fold-containing family a member 1 (Q9NP55) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NP55
Elsewhere: RCSB PDB 4KGO · PDBe 4KGO · UniProt Q9NP55

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