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Crystal structure of light mutant

Analyse Crystal structure of light mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4KG8
Type: protein
Length: 364 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tumor necrosis factor ligand superfamily member 14
UniProt: O43557
Pockets: 3 · best druggability 0.62

Structure

x-ray diffraction · 3 distinct chains · 0% helix, 59% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tumor necrosis factor ligand superfamily member 14	protein	129	0% helix, 60% strand	O43557
B	Tumor necrosis factor ligand superfamily member 14	protein	120	0% helix, 57% strand	O43557
C	Tumor necrosis factor ligand superfamily member 14	protein	115	0% helix, 61% strand	O43557

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	204	0.62	0.83	30	empty
2	118	0.44	0.77	20	empty
3	57	0.29	0.75	12	empty

Interfaces

3 interfaces between chains.

A–C · 907 Å² buried · 18 hydrogen bonds · protein-protein
B–C · 901 Å² buried · 11 hydrogen bonds · protein-protein
A–B · 892 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

4KG8 · Crystal structure of light mutant · the same entry in another collection · chain C against C, TM-score 1.00
O43557 · AlphaFold monomer V2.0 prediction for tumor necrosis factor ligand superfamily member 14… · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43557
Elsewhere: RCSB PDB 4KG8 · PDBe 4KG8 · UniProt O43557

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