Research workbench
NUP188(AA1445-1827) from myceliophthora thermophila
Analyse NUP188(AA1445-1827) from myceliophthora thermophila in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4KF8
- Type
- protein
- Length
- 602 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NUP188
- UniProt
- G2QD05
- Pockets
- 5 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NUP188 | protein | 344 | 66% helix, 1% strand | G2QD05 |
| B | NUP188 | protein | 258 | 71% helix, 0% strand | G2QD05 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.60 | 0.92 | 14 | empty |
| 2 | 82 | 0.52 | 0.84 | 17 | empty |
| 3 | 103 | 0.41 | 0.77 | 21 | empty |
| 4 | 119 | 0.38 | 0.74 | 19 | empty |
| 5 | 74 | 0.28 | 0.72 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 879 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 modified (engineered).
Compared structures
- 4KF8 · Nup188(aa1445-1827) from Myceliophthora thermophila · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G2QD05
- Elsewhere: RCSB PDB 4KF8 · PDBe 4KF8 · UniProt G2QD05
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