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Myotonic dystrophy type 2 RNA: structural studies and designed small molecules that modulate RNA function

Analyse Myotonic dystrophy type 2 RNA: structural studies and designed small molecules… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
4K27
Type
RNA
Length
55 nucleotides
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Myotonic dystrophy type 2 RNA
Ligands
MG, CL
Pockets
2 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain.

ChainMoleculeTypeResiduesSecondary structureUniProt
UMyotonic dystrophy type 2 RNArna55——

Ligands and binding sites

  • MG · Magnesium ion · metal · 3 copies · chains U
  • CL · Chloride ion · ion · 6 copies · chains U

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
15380.580.7327empty
2560.230.7212CL

Compared structures

  • 4K27 · Myotonic Dystrophy Type 2 RNA: Structural Studies and Designed Small Molecules that… · the same entry in another collection · chain U against U, TM-score 1.00

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