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Crystal structure of RRP9 WD40 repeats

Analyse Crystal structure of RRP9 WD40 repeats in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4JXM
Type: protein
Length: 330 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: U3 small nucleolar RNA-interacting protein 2
UniProt: O43818
Ligands: UNX
Pockets: 2 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	U3 small nucleolar RNA-interacting protein 2	protein	330	2% helix, 50% strand	O43818

Ligands and binding sites

UNX · Unknown atom or ion · ion · 9 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	447	0.83	0.90	50	UNX
2	95	0.37	0.75	20	empty

Compared structures

4JXM · Crystal structure of RRP9 WD40 repeats · the same entry in another collection · chain A against A, TM-score 1.00
O43818 · AlphaFold monomer V2.0 prediction for U3 small nucleolar RNA- interacting protein 2… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43818
Elsewhere: RCSB PDB 4JXM · PDBe 4JXM · UniProt O43818

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