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Human procaspase-3, crystal form 2

Analyse Human procaspase-3, crystal form 2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4JQZ
Type: protein
Length: 379 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Procaspase-3
EC: 3.4.22.56
UniProt: P42574
Pockets: 3 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Procaspase-3 (EC 3.4.22.56)	protein	197	34% helix, 24% strand	P42574
B	Procaspase-3 (EC 3.4.22.56)	protein	182	37% helix, 22% strand	P42574

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	455	0.63	0.77	61	empty
2	94	0.47	0.81	18	empty
3	89	0.32	0.73	22	empty

Interfaces

1 interface between chains.

A–B · 1137 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

4JQZ · Human procaspase-3, crystal form 2 · the same entry in another collection · chain A against A, TM-score 1.00
P42574 · AlphaFold monomer V2.0 prediction for caspase-3 (P42574) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42574
Elsewhere: RCSB PDB 4JQZ · PDBe 4JQZ · UniProt P42574

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