Research workbench
HLA-B*44:03 in complex with epstein-barr virus BZLF1-derived peptide (residues 169-180)
Analyse HLA-B*44:03 in complex with epstein-barr virus BZLF1-derived peptide (residues… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4JQX
- Type
- protein
- Length
- 387 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, B-44 alpha chain; Beta-2-microglobulin…
- UniProt
- P30481, P61769, Q3KSS8
- Pockets
- 6 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I histocompatibility antigen, B-44 alpha chain | protein | 276 | 28% helix, 40% strand | P30481 |
| C | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | P61769 |
| B | Trans-activator protein BZLF1 | protein | 12 | 0% helix, 0% strand | Q3KSS8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 629 | 0.69 | 0.77 | 56 | GOL |
| 2 | 52 | 0.51 | 0.88 | 19 | empty |
| 3 | 111 | 0.49 | 0.81 | 21 | empty |
| 4 | 69 | 0.41 | 0.80 | 18 | ACT |
| 5 | 56 | 0.35 | 0.78 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–C · 1328 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 1015 Ų buried · 25 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 4JQX · HLA-B*44:03 in complex with Epstein-Barr virus BZLF1-derived peptide (residues 169-180) · the same entry in another collection · chain A against A, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30481
- Every structure of UniProt P61769
- Every structure of UniProt Q3KSS8
- Elsewhere: RCSB PDB 4JQX · PDBe 4JQX · UniProt P30481 · UniProt P61769 · UniProt Q3KSS8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.