Research workbench
Structure of E. COLI pol III 3MPHP mutant
Analyse Structure of E. COLI pol III 3MPHP mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4JOM
- Type
- protein
- Length
- 909 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA polymerase III subunit alpha
- EC
- 2.7.7.7
- UniProt
- P10443
- Ligands
- ZN, PO4
- Pockets
- 9 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA polymerase III subunit alpha (EC 2.7.7.7) | protein | 909 | 52% helix, 10% strand | P10443 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A
- PO4 · Phosphate ion · ion · 3 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 430 | 0.72 | 0.82 | 49 | empty |
| 2 | 380 | 0.65 | 0.80 | 54 | PO4 |
| 3 | 74 | 0.41 | 0.79 | 15 | empty |
| 4 | 87 | 0.41 | 0.78 | 21 | empty |
| 5 | 99 | 0.40 | 0.77 | 20 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10443
- Elsewhere: RCSB PDB 4JOM · PDBe 4JOM · UniProt P10443
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