Research workbench
Crystal structure of MUNC18A and SYNTAXIN1 lacking N-peptide complex
Analyse Crystal structure of MUNC18A and SYNTAXIN1 lacking N-peptide complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4JEH
- Type
- protein
- Length
- 777 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Syntaxin-binding protein 1; Syntaxin-1A
- UniProt
- P61765, P32851
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 56% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Syntaxin-binding protein 1 | protein | 556 | 47% helix, 15% strand | P61765 |
| B | Syntaxin-1A | protein | 221 | 80% helix, 0% strand | P32851 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1086 | 0.78 | 0.80 | 144 | empty |
| 2 | 532 | 0.67 | 0.78 | 50 | empty |
| 3 | 155 | 0.51 | 0.79 | 23 | empty |
| 4 | 135 | 0.46 | 0.77 | 17 | empty |
| 5 | 77 | 0.40 | 0.79 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 2284 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 4JEH · Crystal Structure of Munc18a and Syntaxin1 lacking N-peptide complex · the same entry in another collection · chain A against A, TM-score 1.00
- P61765 · AlphaFold monomer V2.0 prediction for syntaxin-binding protein 1 (P61765) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P32851 · AlphaFold monomer V2.0 prediction for syntaxin-1A (P32851) · a predicted model of the same protein · chain B against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61765
- Every structure of UniProt P32851
- Elsewhere: RCSB PDB 4JEH · PDBe 4JEH · UniProt P61765 · UniProt P32851
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