Research workbench
Crystal structure of hops component VPS33 from chaetomium thermophilum
Analyse Crystal structure of hops component VPS33 from chaetomium thermophilum in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4JC8
- Type
- protein
- Length
- 1,179 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hops component VPS33
- Pockets
- 20 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hops component VPS33 | protein | 590 | 52% helix, 16% strand | — |
| B | Hops component VPS33 | protein | 589 | 50% helix, 16% strand | — |
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 163 | 0.60 | 0.83 | 19 | empty |
| 2 | 165 | 0.59 | 0.82 | 20 | empty |
| 3 | 154 | 0.58 | 0.82 | 21 | empty |
| 4 | 278 | 0.55 | 0.77 | 39 | empty |
| 5 | 312 | 0.54 | 0.75 | 40 | empty |
Interfaces
1 interface between chains.
- A–B · 1499 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 modified (engineered).
Compared structures
- 4JC8 · Crystal Structure of HOPS component Vps33 from Chaetomium thermophilum · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4JC8 · PDBe 4JC8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.