Research workbench
Immune activator bound to receptor
Analyse Immune activator bound to receptor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4JC5
- Type
- protein
- Length
- 370 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transmembrane protein 173
- UniProt
- Q3TBT3
- Ligands
- 1K5
- Pockets
- 5 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transmembrane protein 173 | protein | 187 | 40% helix, 23% strand | Q3TBT3 |
| B | Transmembrane protein 173 | protein | 183 | 40% helix, 22% strand | Q3TBT3 |
Ligands and binding sites
- 1K5 · (9-oxoacridin-10(9H)-yl)acetic acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 223 | 0.81 | 0.94 | 33 | 1K5 |
| 2 | 214 | 0.69 | 0.86 | 37 | empty |
| 3 | 77 | 0.51 | 0.84 | 19 | empty |
| 4 | 84 | 0.43 | 0.79 | 17 | empty |
| 5 | 78 | 0.40 | 0.78 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1512 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3TBT3
- Elsewhere: RCSB PDB 4JC5 · PDBe 4JC5 · UniProt Q3TBT3
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