Research workbench
Structure of murine DNA binding protein bound with ds DNA
Analyse Structure of murine DNA binding protein bound with ds DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4JBM
- Type
- protein + DNA
- Length
- 401 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon-inducible protein AIM2; DNA (5'-D(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3')
- UniProt
- Q91VJ1
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 3 distinct chains · 8% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interferon-inducible protein AIM2 | protein | 190 | 9% helix, 47% strand | Q91VJ1 |
| B | Interferon-inducible protein AIM2 | protein | 187 | 8% helix, 52% strand | Q91VJ1 |
| T, R | DNA (5'-D(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3') | dna | 12 | — | — |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 621 | 0.70 | 0.79 | 54 | empty |
| 2 | 253 | 0.63 | 0.81 | 36 | empty |
| 3 | 282 | 0.51 | 0.74 | 26 | empty |
| 4 | 50 | 0.26 | 0.74 | 13 | empty |
Interfaces
4 interfaces between chains.
- T–R · 572 Ų buried · 57 hydrogen bonds · nucleic-nucleic
- A–R · 260 Ų buried · 3 hydrogen bonds · protein-nucleic
- A–T · 211 Ų buried · 5 hydrogen bonds · protein-nucleic
- B–T · 159 Ų buried · 5 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4JBM · Structure of murine DNA binding protein bound with ds DNA · the same entry in another collection · chain A against A, TM-score 1.00
- Q91VJ1 · AlphaFold monomer V2.0 prediction for interferon-inducible protein AIM2 (Q91VJ1) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q91VJ1
- Elsewhere: RCSB PDB 4JBM · PDBe 4JBM · UniProt Q91VJ1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.