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Crystal structure of beta'-COP/HWBP1 complex
Analyse Crystal structure of beta'-COP/HWBP1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4J77
- Type
- protein
- Length
- 610 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- WBP1; Coatomer subunit beta'
- UniProt
- P41811
- Pockets
- 4 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 2% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | WBP1 | protein | 5 | 0% helix, 0% strand | — |
| A | Coatomer subunit beta' | protein | 300 | 3% helix, 54% strand | P41811 |
| B | Coatomer subunit beta' | protein | 299 | 2% helix, 54% strand | P41811 |
| D | WBP1 | protein | 6 | 0% helix, 0% strand | — |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 694 | 0.80 | 0.84 | 56 | empty |
| 2 | 694 | 0.79 | 0.84 | 57 | empty |
| 3 | 64 | 0.43 | 0.82 | 17 | empty |
| 4 | 110 | 0.37 | 0.74 | 26 | empty |
Interfaces
3 interfaces between chains.
- A–B · 582 Ų buried · 16 hydrogen bonds · protein-protein
- C–A · 439 Ų buried · 16 hydrogen bonds · protein-protein
- B–D · 437 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P41811
- Elsewhere: RCSB PDB 4J77 · PDBe 4J77 · UniProt P41811
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