Research workbench
Crystal structure of eschelichia COLI branched-chain amino acid aminotransferase.
Analyse Crystal structure of eschelichia COLI branched-chain amino acid… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1I1L
- Type
- protein
- Length
- 912 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Branched-chain amino acid aminotransferase
- EC
- 2.6.1.42
- UniProt
- P00510
- Ligands
- PLP, 2ML
- Pockets
- 10 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Branched-chain amino acid aminotransferase (EC 2.6.1.42) | protein | 304 | 29% helix, 26% strand | P00510 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · 3 copies · chains A, B, C
- 2ML · 2-methylleucine · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1095 | 0.84 | 0.84 | 99 | empty |
| 2 | 365 | 0.73 | 0.84 | 34 | empty |
| 3 | 226 | 0.70 | 0.87 | 42 | PLP, 2ML |
| 4 | 240 | 0.70 | 0.86 | 42 | PLP, 2ML |
| 5 | 375 | 0.69 | 0.81 | 58 | PLP, 2ML |
Interfaces
3 interfaces between chains.
- B–C · 660 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 659 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 657 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 1I1L · Crystal structure of eschelichia COLI branched-chain amino acid aminotransferase. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00510
- Elsewhere: RCSB PDB 1I1L · PDBe 1I1L · UniProt P00510
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.