Research workbench

Crystal structure of 16S ribosomal RNA methyltransferase rsme

Analyse Crystal structure of 16S ribosomal RNA methyltransferase rsme in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4J3C
Type: protein
Length: 466 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribosomal RNA small subunit methyltransferase E
EC: 2.1.1.193
UniProt: Q92RS8
Pockets: 6 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribosomal RNA small subunit methyltransferase E (EC 2.1.1.193)	protein	232	26% helix, 24% strand	Q92RS8
B	Ribosomal RNA small subunit methyltransferase E (EC 2.1.1.193)	protein	234	30% helix, 23% strand	Q92RS8

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	323	0.62	0.79	32	empty
2	269	0.55	0.76	31	empty
3	142	0.46	0.77	30	empty
4	74	0.46	0.81	17	empty
5	70	0.37	0.78	19	empty

Interfaces

1 interface between chains.

A–B · 1576 Å² buried · 33 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 modified (engineered).

Compared structures

4J3C · Crystal structure of 16S ribosomal RNA methyltransferase RsmE · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92RS8
Elsewhere: RCSB PDB 4J3C · PDBe 4J3C · UniProt Q92RS8

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.