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Crystal structure of IFIT5/ISG58

Analyse Crystal structure of IFIT5/ISG58 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4J0U
Type: protein
Length: 471 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interferon-induced protein with tetratricopeptide repeats 5
UniProt: Q13325
Pockets: 4 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interferon-induced protein with tetratricopeptide repeats 5	protein	471	75% helix, 0% strand	Q13325

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	328	0.73	0.85	38	empty
2	586	0.71	0.79	43	empty
3	112	0.39	0.75	21	empty
4	78	0.32	0.74	23	empty

Compared structures

4J0U · Crystal structure of IFIT5/ISG58 · the same entry in another collection · chain A against A, TM-score 1.00
Q13325 · AlphaFold monomer V2.0 prediction for interferon-induced protein with tetratricopeptide… · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13325
Elsewhere: RCSB PDB 4J0U · PDBe 4J0U · UniProt Q13325

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