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Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, P212121 form
Analyse Structure of a 16 nm protein cage designed by fusing symmetric oligomeric… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ITV
- Type
- protein
- Length
- 5,280 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-haem bromoperoxidase bpo-A2, matrix protein 1
- EC
- 1.11.1.-
- UniProt
- P29715, P03485
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Non-haem bromoperoxidase bpo-A2, matrix protein 1 (EC 1.11.1.-) | protein | 440 | 53% helix, 13% strand | P29715, P03485 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1127 | 0.86 | 0.87 | 102 | empty |
| 2 | 1125 | 0.85 | 0.86 | 114 | empty |
| 3 | 1144 | 0.85 | 0.86 | 107 | empty |
| 4 | 1168 | 0.85 | 0.86 | 109 | empty |
| 5 | 547 | 0.74 | 0.82 | 65 | empty |
Interfaces
28 interfaces between chains.
- A–J · 1172 Ų buried · 14 hydrogen bonds · protein-protein
- I–K · 1162 Ų buried · 11 hydrogen bonds · protein-protein
- B–E · 1161 Ų buried · 12 hydrogen bonds · protein-protein
- J–K · 1014 Ų buried · 13 hydrogen bonds · protein-protein
- D–F · 994 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 4ITV · Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29715
- Every structure of UniProt P03485
- Elsewhere: RCSB PDB 4ITV · PDBe 4ITV · UniProt P29715 · UniProt P03485
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