Research workbench
Crystal structure of wild type turkey delta 1 crystallin (eye lens protein)
Analyse Crystal structure of wild type turkey delta 1 crystallin (eye lens protein) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1I0A
- Type
- protein
- Length
- 1,785 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Delta crystallin I
- EC
- 4.3.2.1
- UniProt
- Q7SIE0
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 67% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Delta crystallin I (EC 4.3.2.1) | protein | 453 | 67% helix, 6% strand | Q7SIE0 |
| B | Delta crystallin I (EC 4.3.2.1) | protein | 444 | 66% helix, 5% strand | Q7SIE0 |
| C | Delta crystallin I (EC 4.3.2.1) | protein | 445 | 67% helix, 6% strand | Q7SIE0 |
| D | Delta crystallin I (EC 4.3.2.1) | protein | 443 | 67% helix, 5% strand | Q7SIE0 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 101 | 0.79 | 0.98 | 24 | empty |
| 2 | 92 | 0.78 | 0.99 | 22 | empty |
| 3 | 726 | 0.77 | 0.82 | 68 | empty |
| 4 | 742 | 0.76 | 0.81 | 64 | empty |
| 5 | 762 | 0.75 | 0.80 | 71 | empty |
Interfaces
6 interfaces between chains.
- B–D · 3854 Ų buried · 66 hydrogen bonds · protein-protein
- A–C · 3845 Ų buried · 67 hydrogen bonds · protein-protein
- A–D · 2004 Ų buried · 29 hydrogen bonds · protein-protein
- C–D · 1819 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 1785 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 1I0A · Crystal structure of wild type turkey delta 1 crystallin (eye lens protein) · the same entry in another collection · chain D against D, TM-score 1.00
- Q7SIE0 · AlphaFold monomer V2.0 prediction for delta-1 crystallin (Q7SIE0) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7SIE0
- Elsewhere: RCSB PDB 1I0A · PDBe 1I0A · UniProt Q7SIE0
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