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Structure of glycogen synthase kinase-3 (GSK3B)

Analyse Structure of glycogen synthase kinase-3 (GSK3B) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1I09
Type: protein
Length: 679 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glycogen synthase kinase-3 beta
EC: 2.7.1.37
UniProt: P49841
Ligands: PO4
Pockets: 8 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glycogen synthase kinase-3 beta (EC 2.7.1.37)	protein	338	36% helix, 19% strand	P49841
B	Glycogen synthase kinase-3 beta (EC 2.7.1.37)	protein	341	33% helix, 20% strand	P49841

Ligands and binding sites

PO4 · Phosphate ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	860	0.74	0.78	70	PO4
2	66	0.70	0.96	23	empty
3	653	0.69	0.77	58	empty
4	114	0.48	0.80	28	empty
5	100	0.44	0.79	27	empty

Interfaces

1 interface between chains.

A–B · 906 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

1I09 · Structure of glycogen synthase kinase-3 (GSK3B) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P49841
Elsewhere: RCSB PDB 1I09 · PDBe 1I09 · UniProt P49841

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