Research workbench
Semet-substituted kluyveromyces lactis allophanate hydrolase
Analyse Semet-substituted kluyveromyces lactis allophanate hydrolase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ISS
- Type
- protein
- Length
- 1,226 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Allophanate hydrolase
- EC
- 3.5.1.54
- UniProt
- Q6CP22
- Pockets
- 15 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Allophanate hydrolase (EC 3.5.1.54) | protein | 614 | 34% helix, 20% strand | Q6CP22 |
| B | Allophanate hydrolase (EC 3.5.1.54) | protein | 612 | 33% helix, 20% strand | Q6CP22 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 897 | 0.74 | 0.78 | 61 | empty |
| 2 | 330 | 0.67 | 0.81 | 38 | TAR |
| 3 | 301 | 0.67 | 0.82 | 44 | GOL |
| 4 | 238 | 0.54 | 0.77 | 45 | empty |
| 5 | 301 | 0.54 | 0.75 | 43 | empty |
Interfaces
1 interface between chains.
- A–B · 2621 Ų buried · 32 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 modified (engineered).
Compared structures
- 4ISS · SeMet-substituted Kluyveromyces lactis Allophanate Hydrolase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6CP22
- Elsewhere: RCSB PDB 4ISS · PDBe 4ISS · UniProt Q6CP22
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.