Research workbench
The glutamine synthetase from the dicotyledonous plant M. truncatula is a decamer
Analyse The glutamine synthetase from the dicotyledonous plant M. truncatula is a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4IS4
- Type
- protein
- Length
- 3,078 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamine synthetase
- EC
- 6.3.1.2
- UniProt
- O04998
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 10 distinct chains · 31% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamine synthetase (EC 6.3.1.2) | protein | 339 | 32% helix, 25% strand | O04998 |
| B | Glutamine synthetase (EC 6.3.1.2) | protein | 306 | 31% helix, 26% strand | O04998 |
| C | Glutamine synthetase (EC 6.3.1.2) | protein | 311 | 31% helix, 27% strand | O04998 |
| D | Glutamine synthetase (EC 6.3.1.2) | protein | 304 | 31% helix, 27% strand | O04998 |
| E | Glutamine synthetase (EC 6.3.1.2) | protein | 293 | 31% helix, 27% strand | O04998 |
| F | Glutamine synthetase (EC 6.3.1.2) | protein | 307 | 31% helix, 27% strand | O04998 |
| G | Glutamine synthetase (EC 6.3.1.2) | protein | 311 | 30% helix, 26% strand | O04998 |
| H | Glutamine synthetase (EC 6.3.1.2) | protein | 302 | 30% helix, 27% strand | O04998 |
| I | Glutamine synthetase (EC 6.3.1.2) | protein | 303 | 31% helix, 27% strand | O04998 |
| J | Glutamine synthetase (EC 6.3.1.2) | protein | 302 | 31% helix, 26% strand | O04998 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 866 | 0.75 | 0.79 | 73 | empty |
| 2 | 554 | 0.65 | 0.76 | 49 | empty |
| 3 | 563 | 0.64 | 0.76 | 50 | empty |
| 4 | 537 | 0.64 | 0.76 | 44 | empty |
| 5 | 241 | 0.61 | 0.80 | 34 | empty |
Interfaces
25 interfaces between chains.
- A–E · 1895 Ų buried · 32 hydrogen bonds · protein-protein
- D–E · 1768 Ų buried · 29 hydrogen bonds · protein-protein
- I–J · 1731 Ų buried · 29 hydrogen bonds · protein-protein
- G–H · 1728 Ų buried · 29 hydrogen bonds · protein-protein
- F–J · 1721 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 4IS4 · The glutamine synthetase from the dicotyledonous plant M. truncatula is a decamer · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O04998
- Elsewhere: RCSB PDB 4IS4 · PDBe 4IS4 · UniProt O04998
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