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Mutant P44S P169S M296I of foot-and-mouth disease virus RNA-dependent RNA polymerase

Analyse Mutant P44S P169S M296I of foot-and-mouth disease virus RNA-dependent RNA… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4IQX
Type: protein + RNA
Length: 488 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3D polymerase; RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'); RNA (5'-R(*GP*GP*CP*CP*C)-3')
UniProt: Q9QCE4
Pockets: 2 · best druggability 0.77

Structure

x-ray diffraction · 3 distinct chains · 42% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3D polymerase	protein	476	42% helix, 19% strand	Q9QCE4
B	RNA (5'-R(APUPGPGPGPCP*C)-3')	rna	7	—	—
C	RNA (5'-R(GPGPCPCP*C)-3')	rna	5	—	—

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	938	0.77	0.80	70	empty
2	115	0.62	0.87	26	empty

Interfaces

3 interfaces between chains.

A–B · 947 Å² buried · 25 hydrogen bonds · protein-nucleic
A–C · 602 Å² buried · 7 hydrogen bonds · protein-nucleic
B–C · 244 Å² buried · 27 hydrogen bonds · nucleic-nucleic

Compared structures

4IQX · Mutant P44S P169S M296I of Foot-and-mouth disease Virus RNA-dependent RNA polymerase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9QCE4
Elsewhere: RCSB PDB 4IQX · PDBe 4IQX · UniProt Q9QCE4

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