Research workbench
Crystal structure of OSH3 ord in complex with PI(4)P from saccharomyces cerevisiae
Analyse Crystal structure of OSH3 ord in complex with PI(4)P from saccharomyces… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4INQ
- Type
- protein
- Length
- 372 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Oxysterol-binding protein homolog 3
- UniProt
- P38713
- Ligands
- PIF
- Pockets
- 3 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 25% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Oxysterol-binding protein homolog 3 | protein | 372 | 25% helix, 30% strand | P38713 |
Ligands and binding sites
- PIF · (2R)-3-{[(S)-hydroxy{[(1r,2r,3r,4r,5s,6r)-2,3,5,6-tetrahydroxy-4-(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 741 | 0.83 | 0.86 | 65 | PIF |
| 2 | 69 | 0.32 | 0.75 | 21 | empty |
| 3 | 60 | 0.28 | 0.73 | 14 | empty |
Compared structures
- 4INQ · Crystal structure of Osh3 ORD in complex with PI(4)P from Saccharomyces cerevisiae · the same entry in another collection · chain A against A, TM-score 1.00
- P38713 · AlphaFold monomer V2.0 prediction for oxysterol-binding protein homolog 3 (P38713) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38713
- Elsewhere: RCSB PDB 4INQ · PDBe 4INQ · UniProt P38713
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