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Crystal structure of the Q7MSS8_WOLSU protein from wolinella succinogenes. northeast structural genomics consortium target WSR35

Analyse Crystal structure of the Q7MSS8_WOLSU protein from wolinella succinogenes.… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4INA
Type: protein
Length: 791 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Saccharopine dehydrogenase
EC: 1.5.1.7
UniProt: Q7MSS8
Pockets: 2 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Saccharopine dehydrogenase (EC 1.5.1.7)	protein	394	38% helix, 29% strand	Q7MSS8
B	Saccharopine dehydrogenase (EC 1.5.1.7)	protein	397	38% helix, 28% strand	Q7MSS8

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1061	0.83	0.84	96	empty
2	1075	0.80	0.82	91	empty

Interfaces

1 interface between chains.

A–B · 934 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 28 modified (engineered).

Compared structures

4INA · Crystal Structure of the Q7MSS8_WOLSU protein from Wolinella succinogenes. Northeast… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7MSS8
Elsewhere: RCSB PDB 4INA · PDBe 4INA · UniProt Q7MSS8

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