Research workbench

Crystal structure of peptide transporter pot (E310Q mutant) in complex with alafosfalin

Analyse Crystal structure of peptide transporter pot (E310Q mutant) in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4IKZ
Type: protein
Length: 485 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Di-tripeptide ABC transporter (permease)
Ligands: AFS, SO4
Pockets: 4 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 79% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Di-tripeptide ABC transporter (permease)	protein	485	79% helix, 2% strand	—

Ligands and binding sites

AFS · N-[(1R)-1-phosphonoethyl]-L-alaninamide · ligand · chains A
SO4 · Sulfate ion · ion · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	777	0.76	0.80	70	AFS
2	124	0.47	0.78	25	empty
3	112	0.40	0.75	21	empty
4	72	0.37	0.76	12	empty

Compared structures

4IKZ · Crystal structure of peptide transporter POT (E310Q mutant) in complex with alafosfalin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4IKZ · PDBe 4IKZ

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.