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Crystal structure of the delta-pyrroline-5-carboxylate dehydrogenase from mycobacterium tuberculosis

Analyse Crystal structure of the delta-pyrroline-5-carboxylate dehydrogenase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4IDS
Type: protein
Length: 541 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Delta-1-pyrroline-5-carboxylate dehydrogenase
EC: 1.5.1.12
UniProt: I6X0K4
Pockets: 5 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12)	protein	541	41% helix, 21% strand	I6X0K4

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	289	0.78	0.90	46	empty
2	601	0.69	0.77	59	empty
3	85	0.58	0.87	18	empty
4	153	0.42	0.74	23	empty
5	100	0.37	0.75	18	empty

Modifications

Observed in the structure: 1 modified (artifact).

Compared structures

4IDS · Crystal structure of the Delta-pyrroline-5-carboxylate dehydrogenase from Mycobacterium… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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Every structure of UniProt I6X0K4
Elsewhere: RCSB PDB 4IDS · PDBe 4IDS · UniProt I6X0K4

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