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The 1.8 a structure of collagenase from hypoderma lineatum

Analyse The 1.8 a structure of collagenase from hypoderma lineatum in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1HYL
Type: protein
Length: 460 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hypoderma lineatum collagenase
EC: 3.4.21.-
UniProt: P08897
Pockets: 1 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Hypoderma lineatum collagenase (EC 3.4.21.-)	protein	230	11% helix, 38% strand	P08897

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	269	0.61	0.80	58	empty

Interfaces

1 interface between chains.

A–B · 1128 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

1HYL · The 1.8 a structure of collagenase from hypoderma lineatum · the same entry in another collection · chain A against A, TM-score 1.00
P08897 · AlphaFold monomer V2.0 prediction for collagenase (P08897) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08897
Elsewhere: RCSB PDB 1HYL · PDBe 1HYL · UniProt P08897

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