Research workbench
N-terminal dimerization domain of H-ns in complex with hha (salmonella typhimurium)
Analyse N-terminal dimerization domain of H-ns in complex with hha (salmonella… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ICG
- Type
- protein
- Length
- 223 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-binding protein H-ns; Hemolysin expression modulating protein (involved in…
- UniProt
- P0A1S2, Q7CR17
- Pockets
- 4 · best druggability 0.50
Structure
x-ray diffraction · 3 distinct chains · 64% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | DNA-binding protein H-ns | protein | 44 | 80% helix, 0% strand | P0A1S2 |
| C | Hemolysin expression modulating protein (involved in environmental regulation of virulence factors) | protein | 67 | 61% helix, 0% strand | Q7CR17 |
| D | Hemolysin expression modulating protein (involved in environmental regulation of virulence factors) | protein | 68 | 57% helix, 0% strand | Q7CR17 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.50 | 0.86 | 18 | empty |
| 2 | 86 | 0.50 | 0.82 | 22 | empty |
| 3 | 125 | 0.45 | 0.78 | 29 | empty |
| 4 | 60 | 0.35 | 0.77 | 12 | empty |
Interfaces
5 interfaces between chains.
- B–A · 1726 Ų buried · 22 hydrogen bonds · protein-protein
- A–D · 387 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 363 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 336 Ų buried · 4 hydrogen bonds · protein-protein
- C–A · 301 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 4ICG · N-terminal dimerization domain of H-NS in complex with Hha (Salmonella Typhimurium) · the same entry in another collection · chain B against B, TM-score 1.00
- Q7CR17 · AlphaFold monomer V2.0 prediction for hemolysin expression-modulating protein hha (Q7CR17) · a predicted model of the same protein · chain C against A, TM-score 0.95
- P0A1S2 · AlphaFold monomer V2.0 prediction for DNA-binding protein H-ns (P0A1S2) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A1S2
- Every structure of UniProt Q7CR17
- Elsewhere: RCSB PDB 4ICG · PDBe 4ICG · UniProt P0A1S2 · UniProt Q7CR17
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.