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R107G HSP16.5

Analyse R107G HSP16.5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4I88
Type: protein
Length: 911 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Small heat shock protein HSP16.5
UniProt: Q57733
Pockets: 16 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Small heat shock protein HSP16.5	protein	113	8% helix, 50% strand	Q57733
B, C, D, E, F, G, H	Small heat shock protein HSP16.5	protein	114	8% helix, 49% strand	Q57733

Pockets

16 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	186	0.55	0.80	28	empty
2	198	0.54	0.79	28	empty
3	197	0.53	0.78	29	empty
4	183	0.53	0.79	26	empty
5	194	0.53	0.78	27	empty

Interfaces

13 interfaces between chains.

B–D · 1806 Å² buried · 26 hydrogen bonds · protein-protein
G–H · 1796 Å² buried · 26 hydrogen bonds · protein-protein
A–C · 1789 Å² buried · 27 hydrogen bonds · protein-protein
D–H · 643 Å² buried · 7 hydrogen bonds · protein-protein
C–G · 642 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

4I88 · R107G HSP16.5 · the same entry in another collection · chain H against H, TM-score 1.00
Q57733 · AlphaFold monomer V2.0 prediction for small heat shock protein HSP16.5 (Q57733) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q57733
Elsewhere: RCSB PDB 4I88 · PDBe 4I88 · UniProt Q57733

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