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Crystal structure of pilz domain of cesa from cellulose synthesizing bacterium

Analyse Crystal structure of pilz domain of cesa from cellulose synthesizing bacterium in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4I86
Type: protein
Length: 200 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cellulose synthase 1
EC: 2.4.1.12
UniProt: P0CW87
Pockets: 2 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 15% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cellulose synthase 1 (EC 2.4.1.12)	protein	102	15% helix, 47% strand	P0CW87
B	Cellulose synthase 1 (EC 2.4.1.12)	protein	98	15% helix, 50% strand	P0CW87

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	165	0.54	0.80	21	empty
2	169	0.47	0.76	34	empty

Interfaces

1 interface between chains.

A–B · 493 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

4I86 · Crystal structure of PilZ domain of CeSA from cellulose synthesizing bacterium · the same entry in another collection · chain A against A, TM-score 1.00
P0CW87 · AlphaFold monomer V2.0 prediction for cellulose synthase 1 (P0CW87) · a predicted model of the same protein · chain B against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0CW87
Elsewhere: RCSB PDB 4I86 · PDBe 4I86 · UniProt P0CW87

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