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Crystal structure of human NUP43

Analyse Crystal structure of human NUP43 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4I79
Type: protein
Length: 641 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoporin NUP43; Floating chain, unknown sequence
UniProt: Q8NFH3
Ligands: UNX
Pockets: 4 · best druggability 0.74

Structure

x-ray diffraction · 3 distinct chains · 0% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoporin NUP43	protein	316	0% helix, 52% strand	Q8NFH3
B	Nucleoporin NUP43	protein	316	0% helix, 52% strand	Q8NFH3
C	Floating chain, unknown sequence	protein	9	0% helix, 0% strand	—

Ligands and binding sites

UNX · Unknown atom or ion · ion · 32 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	705	0.74	0.80	51	UNX
2	682	0.73	0.80	50	UNX
3	187	0.45	0.74	34	UNX
4	104	0.36	0.74	15	empty

Interfaces

2 interfaces between chains.

A–B · 400 Å² buried · 5 hydrogen bonds · protein-protein
B–C · 205 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

4I79 · Crystal structure of human NUP43 · the same entry in another collection · chain A against A, TM-score 1.00
Q8NFH3 · AlphaFold monomer V2.0 prediction for nucleoporin NUP43 (Q8NFH3) · a predicted model of the same protein · chain B against A, TM-score 0.99

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Every structure of UniProt Q8NFH3
Elsewhere: RCSB PDB 4I79 · PDBe 4I79 · UniProt Q8NFH3

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