Research workbench
Comamonas testosteroni 3BETA/17BETA hydroxysteroid dehydrogenase
Analyse Comamonas testosteroni 3BETA/17BETA hydroxysteroid dehydrogenase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1HXH
- Type
- protein
- Length
- 1,012 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3BETA/17BETA-hydroxysteroid dehydrogenase
- EC
- 1.1.1.51
- UniProt
- P19871
- Pockets
- 11 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | 3BETA/17BETA-hydroxysteroid dehydrogenase (EC 1.1.1.51) | protein | 253 | 46% helix, 17% strand | P19871 |
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1177 | 0.84 | 0.85 | 77 | empty |
| 2 | 562 | 0.72 | 0.80 | 49 | empty |
| 3 | 566 | 0.71 | 0.79 | 54 | empty |
| 4 | 517 | 0.70 | 0.79 | 40 | empty |
| 5 | 537 | 0.68 | 0.78 | 51 | empty |
Interfaces
6 interfaces between chains.
- A–C · 1808 Ų buried · 25 hydrogen bonds · protein-protein
- B–D · 1797 Ų buried · 22 hydrogen bonds · protein-protein
- A–D · 1756 Ų buried · 27 hydrogen bonds · protein-protein
- B–C · 1668 Ų buried · 25 hydrogen bonds · protein-protein
- A–B · 413 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1HXH · Comamonas testosteroni 3BETA/17BETA hydroxysteroid dehydrogenase · the same entry in another collection · chain D against D, TM-score 1.00
- P19871 · AlphaFold monomer V2.0 prediction for 3-beta-hydroxysteroid dehydrogenase (P19871) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19871
- Elsewhere: RCSB PDB 1HXH · PDBe 1HXH · UniProt P19871
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