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The crystal structure of an epoxide hydrolase from streptomyces carzinostaticus subsp. neocarzinostaticus.

Analyse The crystal structure of an epoxide hydrolase from streptomyces carzinostaticus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4I19
Type: protein
Length: 386 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Epoxide hydrolase
UniProt: Q84HB8
Pockets: 2 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Epoxide hydrolase	protein	386	51% helix, 15% strand	Q84HB8

Ligands and binding sites

FMT · Formic acid · additive · 10 copies · chains A
ACT · Acetate ion · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	300	0.76	0.88	42	ACT, FMT
2	201	0.47	0.74	33	empty

Modifications

Observed in the structure: 11 modified (engineered).

Compared structures

4I19 · The crystal structure of an epoxide hydrolase from Streptomyces carzinostaticus subsp.… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q84HB8
Elsewhere: RCSB PDB 4I19 · PDBe 4I19 · UniProt Q84HB8

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