Research workbench
Structure of a bacterial energy-coupling factor transporter
Analyse Structure of a bacterial energy-coupling factor transporter in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4HZU
- Type
- protein
- Length
- 961 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Energy-coupling factor transporter ATP-binding protein ecfa 1; Energy-coupling factor…
- EC
- 3.6.3.-
- UniProt
- Q03PY6, Q03PY5, Q03PY7, Q03NM0
- Pockets
- 11 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 53% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Energy-coupling factor transporter ATP-binding protein ecfa 1 (EC 3.6.3.-) | protein | 284 | 41% helix, 20% strand | Q03PY6 |
| A | Energy-coupling factor transporter ATP-binding protein ecfa 2 (EC 3.6.3.-) | protein | 273 | 39% helix, 19% strand | Q03PY5 |
| T | Energy-coupling factor transporter transmembrane protein ecft | protein | 240 | 70% helix, 0% strand | Q03PY7 |
| S | Predicted membrane protein | protein | 164 | 73% helix, 1% strand | Q03NM0 |
Pockets
11 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 949 | 0.80 | 0.82 | 90 | empty |
| 2 | 901 | 0.77 | 0.80 | 78 | empty |
| 3 | 534 | 0.76 | 0.83 | 49 | empty |
| 4 | 313 | 0.67 | 0.82 | 43 | empty |
| 5 | 154 | 0.60 | 0.83 | 26 | empty |
Interfaces
5 interfaces between chains.
- T–S · 2789 Ų buried · 5 hydrogen bonds · protein-protein
- B–A · 1516 Ų buried · 12 hydrogen bonds · protein-protein
- A–T · 1401 Ų buried · 12 hydrogen bonds · protein-protein
- B–T · 757 Ų buried · 6 hydrogen bonds · protein-protein
- B–S · 87 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 4HZU · Structure of a bacterial energy-coupling factor transporter · the same entry in another collection · chain B against B, TM-score 1.00
- Q03PY6 · AlphaFold monomer V2.0 prediction for energy-coupling factor transporter ATP-binding… · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q03PY5 · AlphaFold monomer V2.0 prediction for energy-coupling factor transporter ATP-binding… · a predicted model of the same protein · chain A against A, TM-score 0.92
- Q03PY7 · AlphaFold monomer V2.0 prediction for energy-coupling factor transporter transmembrane… · a predicted model of the same protein · chain T against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03PY6
- Every structure of UniProt Q03PY5
- Every structure of UniProt Q03PY7
- Every structure of UniProt Q03NM0
- Elsewhere: RCSB PDB 4HZU · PDBe 4HZU · UniProt Q03PY6 · UniProt Q03PY5 · UniProt Q03PY7 · UniProt Q03NM0
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