Research workbench
Structure of a serine protease MYCP1, an essential component of the type VII (esx-1) secretion system
Analyse Structure of a serine protease MYCP1, an essential component of the type VII… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4HVL
- Type
- protein
- Length
- 369 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Membrane-anchored mycosin MYCP1
- UniProt
- G7CDQ2
- Ligands
- ZN, CL
- Pockets
- 4 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Membrane-anchored mycosin MYCP1 | protein | 369 | 26% helix, 21% strand | G7CDQ2 |
Ligands and binding sites
- ZN · Zinc ion · metal · 7 copies · chains A
- CL · Chloride ion · ion · chains A
- IMD · Imidazole · additive · 3 copies · chains A
- ACT · Acetate ion · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 598 | 0.68 | 0.78 | 51 | ZN, ACT, CL |
| 2 | 67 | 0.32 | 0.75 | 20 | empty |
| 3 | 56 | 0.28 | 0.74 | 18 | ACT |
| 4 | 58 | 0.26 | 0.73 | 15 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4HVL · Structure of a serine protease MycP1, an essential component of the type VII (ESX-1)… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G7CDQ2
- Elsewhere: RCSB PDB 4HVL · PDBe 4HVL · UniProt G7CDQ2
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