Research workbench

Mate transporter norm-ng in complex with ethidium and monobody

Analyse Mate transporter norm-ng in complex with ethidium and monobody in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4HUM
Type: protein
Length: 550 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Multidrug efflux protein; Protein B
UniProt: E8SM44
Ligands: ET
Pockets: 8 · best druggability 0.87

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Multidrug efflux protein	protein	459	38% helix, 0% strand	E8SM44
B	Protein B	protein	91	0% helix, 24% strand	—

Ligands and binding sites

ET · Ethidium · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1085	0.87	0.88	110	ET
2	200	0.74	0.90	31	empty
3	106	0.64	0.89	24	empty
4	57	0.57	0.89	21	empty
5	61	0.52	0.87	27	empty

Interfaces

1 interface between chains.

A–B · 535 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

4HUM · MATE transporter NorM-NG in complex with ethidium and monobody · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E8SM44
Elsewhere: RCSB PDB 4HUM · PDBe 4HUM · UniProt E8SM44

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