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Crystal structure of CXCL4L1

Analyse Crystal structure of CXCL4L1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4HSV
Type: protein
Length: 248 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Platelet factor 4 variant
UniProt: P10720
Pockets: 6 · best druggability 0.77

Structure

x-ray diffraction · 3 distinct chains · 21% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D	Platelet factor 4 variant	protein	65	20% helix, 34% strand	P10720
B	Platelet factor 4 variant	protein	59	22% helix, 31% strand	P10720
C	Platelet factor 4 variant	protein	59	22% helix, 31% strand	P10720

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	383	0.77	0.87	61	empty
2	220	0.48	0.73	38	empty
3	114	0.45	0.78	29	empty
4	69	0.42	0.80	16	empty
5	123	0.40	0.74	23	empty

Interfaces

6 interfaces between chains.

A–D · 689 Å² buried · 10 hydrogen bonds · protein-protein
B–C · 614 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 382 Å² buried · 11 hydrogen bonds · protein-protein
C–D · 367 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 172 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

4HSV · Crystal Structure of CXCL4L1 · the same entry in another collection · chain A against A, TM-score 1.00
P10720 · AlphaFold monomer V2.0 prediction for platelet factor 4 variant (P10720) · a predicted model of the same protein · chain B against A, TM-score 0.79

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10720
Elsewhere: RCSB PDB 4HSV · PDBe 4HSV · UniProt P10720

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