Research workbench
Crystal structure of P11-annexin A2(N-terminal) fusion protein in complex with AHNAK1 peptide
Analyse Crystal structure of P11-annexin A2(N-terminal) fusion protein in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4HRG
- Type
- protein
- Length
- 243 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein S100-A10; Neuroblast differentiation-associated protein ahnak
- UniProt
- P60903, Q09666
- Pockets
- 2 · best druggability 0.34
Structure
x-ray diffraction · 3 distinct chains · 60% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein S100-A10 | protein | 114 | 64% helix, 4% strand | P60903 |
| B | Protein S100-A10 | protein | 113 | 61% helix, 4% strand | P60903 |
| C, D | Neuroblast differentiation-associated protein ahnak | protein | 8 | 0% helix, 25% strand | Q09666 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 108 | 0.34 | 0.72 | 22 | empty |
| 2 | 57 | 0.26 | 0.73 | 19 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2031 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 693 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 654 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 118 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 71 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4HRG · Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with AHNAK1… · the same entry in another collection · chain A against A, TM-score 1.00
- P60903 · AlphaFold monomer V2.0 prediction for protein S100-A10 (P60903) · a predicted model of the same protein · chain A against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60903
- Every structure of UniProt Q09666
- Elsewhere: RCSB PDB 4HRG · PDBe 4HRG · UniProt P60903 · UniProt Q09666
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