Research workbench
Crystal structure of P11/ANNEXIN A2 heterotetramer in complex with SMARCA3 peptide
Analyse Crystal structure of P11/ANNEXIN A2 heterotetramer in complex with SMARCA3… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4HRE
- Type
- protein
- Length
- 1,752 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Annexin A2; Protein S100-A10; Helicase-like transcription factor
- EC
- 3.6.4.-, 6.3.2.-
- UniProt
- P07356, P60903, Q14527
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 65% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, B, D | Annexin A2 | protein | 338 | 68% helix, 0% strand | P07356 |
| E, F, I, J | Protein S100-A10 | protein | 91 | 60% helix, 2% strand | P60903 |
| G, H, K, L | Helicase-like transcription factor (EC 3.6.4.-, 6.3.2.-) | protein | 9 | 0% helix, 11% strand | Q14527 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 680 | 0.75 | 0.81 | 79 | empty |
| 2 | 1187 | 0.74 | 0.77 | 76 | empty |
| 3 | 695 | 0.73 | 0.79 | 78 | empty |
| 4 | 327 | 0.69 | 0.83 | 39 | empty |
| 5 | 59 | 0.69 | 0.96 | 17 | empty |
Interfaces
26 interfaces between chains.
- E–F · 1411 Ų buried · 8 hydrogen bonds · protein-protein
- I–J · 1370 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 1220 Ų buried · 21 hydrogen bonds · protein-protein
- A–E · 740 Ų buried · 4 hydrogen bonds · protein-protein
- D–J · 733 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4HRE · Crystal Structure of p11/Annexin A2 Heterotetramer in Complex with SMARCA3 Peptide · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07356
- Every structure of UniProt P60903
- Every structure of UniProt Q14527
- Elsewhere: RCSB PDB 4HRE · PDBe 4HRE · UniProt P07356 · UniProt P60903 · UniProt Q14527
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