Research workbench
Crystal structure of RV144-elicited antibody CH58
Analyse Crystal structure of RV144-elicited antibody CH58 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4HQQ
- Type
- protein
- Length
- 427 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CH58 Fab heavy chain; CH58 Fab light chain
- Pockets
- 3 · best druggability 0.39
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | CH58 Fab heavy chain | protein | 215 | 7% helix, 54% strand | — |
| L | CH58 Fab light chain | protein | 212 | 8% helix, 50% strand | — |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 133 | 0.39 | 0.74 | 28 | empty |
| 2 | 110 | 0.35 | 0.73 | 21 | empty |
| 3 | 57 | 0.29 | 0.74 | 10 | empty |
Interfaces
1 interface between chains.
- H–L · 1710 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4HQQ · Crystal structure of RV144-elicited antibody CH58 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4HQQ · PDBe 4HQQ
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