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Crystal structure of plasmodium falciparum trap, P4212 form

Analyse Crystal structure of plasmodium falciparum trap, P4212 form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4HQK
Type: protein
Length: 399 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Thrombospondin-related anonymous protein, trap
UniProt: Q76NM2
Ligands: SO4
Pockets: 2 · best druggability 0.44

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Thrombospondin-related anonymous protein, trap	protein	200	43% helix, 21% strand	Q76NM2
B	Thrombospondin-related anonymous protein, trap	protein	199	41% helix, 22% strand	Q76NM2

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	130	0.44	0.76	17	empty
2	130	0.41	0.75	16	empty

Interfaces

1 interface between chains.

A–B · 553 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4HQK · Crystal structure of Plasmodium falciparum TRAP, P4212 form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q76NM2
Elsewhere: RCSB PDB 4HQK · PDBe 4HQK · UniProt Q76NM2

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